Altered Th17/Treg Ratio in Recurrent Miscarriage after Treatment with Paternal Lymphocytes and Vitamin D3: a Double- Blind Placebo-Controlled Study

نویسندگان

  • Ataollah Ghahiri Department of Gynecology and Obstetrics, Al-Zahra University Hospital
  • Ferdous Mehrabian Department of Gynecology and Obstetrics, Al-Zahra University Hospital
  • Ina Laura Pieper Institute of Life Science, College of Medicine, Swansea University, Swansea, United Kingdom
  • Marjan Gharagozloo Department of Immunology, School of Medicine
  • Mitra Rafiee Department of Immunology, School of Medicine
  • Mohammad R. Maracy Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  • Shirin Kouhpayeh Department of Immunology, School of Medicine
چکیده مقاله:

Background: Recurrent miscarriage (RM) affects 2-5% of pregnant women. Paternal lymphocyte immunotherapy is a common treatment for RM patients but the outcome has not been consistent. Therefore, combined therapy with other immunosuppressive drugs such as 1 a, 25-dihydroxy-vitamin-D3 (vitamin D3) may improve the outcome. Objectives: To investigate the effect of vitamin D3 on the balance of two essential T cells subsets, T helper (Th) 17 and T regulatory (Treg) cells, which contribute to the immune tolerance during pregnancy. Methods: The expression levels of CD4 and forkhead box protein 3 (FOXP3) in Treg cells, and the expression levels of CD4 and IL- 17 in Th17 cells, were evaluated pre- and 3 months post-immunotherapy in RM patients treated with a combination of paternal lymphocytes and vitamin D3 compared with RM patients receiving lymphocyte immunotherapy alone. Results: Vitamin D3 therapy decreased the frequency of Th17 cells in addition to reducing the Th17/Treg ratio in peripheral blood of RM patients compared with the control group (p

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altered th17/treg ratio in recurrent miscarriage after treatment with paternal lymphocytes and vitamin d3: a double- blind placebo-controlled study

background: recurrent miscarriage (rm) affects 2-5% of pregnant women. paternal lymphocyte immunotherapy is a common treatment for rm patients but the outcome has not been consistent. therefore, combined therapy with other immunosuppressive drugs such as 1 a, 25-dihydroxy-vitamin-d3 (vitamin d3) may improve the outcome. objectives: to investigate the effect of vitamin d3 on the balance of two e...

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Altered Th17/Treg Ratio in Recurrent Miscarriage after Treatment with Paternal Lymphocytes and Vitamin D3: a Double-Blind Placebo-Controlled Study.

BACKGROUND Recurrent miscarriage (RM) affects 2-5% of pregnant women. Paternal lymphocyte immunotherapy is a common treatment for RM patients but the outcome has not been consistent. Therefore, combined therapy with other immunosuppressive drugs such as 1a, 25-dihydroxy-vitamin-D3 (vitamin D3) may improve the outcome. OBJECTIVES To investigate the effect of vitamin D3 on the balance of two es...

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عنوان ژورنال

دوره 12  شماره 4

صفحات  252- 262

تاریخ انتشار 2015-12-01

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